We Wrote for the Biomere Blog: Here’s What It’s About
By Hannah Sheehan, Ph.D., CEO, CSO & Co-founder, SauveBio
We’re excited to share that SauveBio’s CEO & CSO, Hannah Sheehan, Ph.D., recently contributed a guest post to the Biomere community blog, and it’s about something we talk about with clients constantly.
The piece is called “Protecting Your Preclinical Investment: The Case for High-Fidelity Cell Sorting,” and it makes a single, pointed argument:
Biology doesn’t happen in averages. It happens in specific cells. When you subject precious preclinical samples to bulk analysis, you risk averaging away the exact signal you designed your study to detect.
In vivo studies are expensive, slow, and irreplaceable. The tissue that comes out of them deserves better than a bulk readout. High-fidelity FACS-based cell sorting is the step that turns tissue-level averages into cellular-resolution data, and it’s the difference between a standard safety study and a genuinely informative mechanistic data package.
In the post, we cover three scenarios where sorting isn’t optional:
- Isolating rare immune subsets (TILs, memory B-cells) that represent <1% of a tissue but drive your entire mechanism of action
- Removing dead cells and debris before scRNA-seq to protect your genomics spend and data quality
- Separating GFP+ transduced cells from bystanders in AAV or CRISPR studies to prove on-target efficacy
Each scenario is grounded in the kind of sample types and study designs we see regularly in gene therapy, cell therapy, and complex biologics programs.
Read the full post on the Biomere blog:
About SauveBio
SauveBio is a Worcester, MA-based flow cytometry and cell sorting CRO. We specialize in FACS-based cell sorting, immunophenotyping, receptor occupancy studies, nanoparticle characterization, antibody validation, and FAMS (fluorescence-activated mitochondrial sorting). We partner with biotech and pharma teams to add cellular resolution to their preclinical and translational workflows.
Want to talk through your study design? Reach out at info@sauvebio.com